To put it simply, a genotype is an individual organism’s genetic makeup. Many times we receive questions like “Can AS marry AS” or Can AA marry AA and so on. In these I’m going to explain everything to you and each of them compatibility.
This is not the same as your phenotype, which is an account of your true physical attributes. Before you say “yes” to that gorgeous boy or woman you want to spend the rest of your life with, or if you are already in a relationship where there is a chance of becoming pregnant, it is crucial to understand your genotype.
Intentional couples should steer clear of the recessive disorder sickle cell disease, which is a dangerous medical ailment with high prevalence rates in Africa south of the Sahara.
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Contents
Types Of Genotype
The genotypes in humans are AA, AS, AC, SS. They refer to the hemoglobin gene constituents on the red blood cells. AC is rare whereas AS and AC are abnormal.
Genotype Compatibility Chart
Study this table below carefully:
AA + AA | = AA, AA, AA, AA (Excellent) |
AA + AS | = AA, AS, AA, AS, (Good) |
AA + SS | = AS, AS, AS, AS, (Fair) |
AA + AC | = AA, AA, AA, AC. (Good) |
AS + AS | = AA, AS, AS, SS, (Very Bad) |
AS + SS | = AS, SS, SS, SS, (Very Bad) |
AS + AC | = AA, AC, AS,SS. (Bad; Advice needed) |
SS + SS | = SS, SS, SS, SS, (Very Bad, You shouldn’t even think about it) |
AC + SS | = AS, AS, SS, SS, (Very Bad) |
AC + AC | AC + AC = AA, AC, AC, SS. ( Bad; Advice needed) |
Compatible Genotype For Marriage
Can AA Marry AA
It is the most harmonious. In this manner, you spare your future offspring the stress of genetic compatibility.
Can AA Marry AS
It is a positive thing that you will have children with AA and AS. However, if you’re not lucky, all the kids might be AS, which would restrict their options for partners.
Can AS Marry AS
Given the likelihood of having a child with SS, AS and AS shouldn’t get married.
SS and AS shouldn’t consider getting married.
Can SS Marry SS
If you’re SS and your partner is SS, both of you should do yourselves a favor of not getting married or having children. Since there’s absolutely no chance of escaping having a child with the sickle cell disease.
Can AA Marry SS
Given the fact that they won’t be having any SS offspring, the genotype are compatibly fair enough to go ahead and marry each other.
Can AA Marry AC
This is very good combination. The both genotype are compatible to each other.
Can AS Marry SS
This combination is not advisable in anyway because you must surely have an SS offspring.
Can AS Marry AC
This combination is advisable also, as you’re likely to have an SS offspring. But if you both must marry, then you need be advised and supervised by a medical professional on ways to avoid having an SS offspring.
Can AC Marry SS
A very bad combination because you would never fail to have an SS offspring should you both marry each other.
Can AC Marry AC
Just like AS vs AC, if you both must marry, then you need be advised and supervised by a medical professional on ways to avoid having an SS offspring. Because you’re likely to have an SS offspring.
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Solution
A bone marrow transplant is the only procedure that has the ability to alter genotype (BMT). It is new, extremely expensive, and cannot be performed anywhere in Africa, but it has been shown to be the only effective long-term treatment for SS, SC, and CC. It is not without risk, though.